738575-62-7
中文名稱(chēng)
化合物 T29186
英文名稱(chēng)
YM-49598
CAS
738575-62-7
分子式
C36H45Cl2N2O2+
分子量
608.67
MOL 文件
738575-62-7.mol
738575-62-7 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
YM49598 is a novel non-peptide tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(2) (pK(i) = 9.94 +/- 0.03) and NK(1) (pK(i) = 9.09 +/- 0.02) receptors, respectively. YM-49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +/- 7 microg x kg(-1)) of the contraction of the rat urinary bladder induced by challenge with the NK(1)-selective receptor agonist [Sar9,Met(O(2))11]substance P sulphone (0.3 microg x kg(-1)).