748142-06-5
英文名稱(chēng)
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-
CAS
748142-06-5
分子式
C19H18N6
分子量
330.39
MOL 文件
748142-06-5.mol
748142-06-5 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures.