75802-84-5
中文名稱
2-氨基-4-(2-氨基-4-氯苯基)-4-氧代丁酸
英文名稱
4-chlorokynurenine
CAS
75802-84-5
分子式
C10H11ClN2O3
分子量
242.66
MOL 文件
75802-84-5.mol
更新日期
2025/04/28 09:18:03
75802-84-5 結(jié)構(gòu)式
基本信息
中文別名
犬尿氨酸雜質(zhì)2化合物 4-CHLOROKYNURENINE
2-氨基-4-(2-氨基-4-氯苯基)-4-氧代丁酸
英文別名
4-chlorokynurenineVitamin A Impurity 17 (13-Cis-Retinal)
Benzenebutanoic acid, α,2-diamino-4-chloro-γ-oxo-
2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
物理化學(xué)性質(zhì)
熔點(diǎn)>165°C (dec.)
沸點(diǎn)516.3±50.0 °C(Predicted)
密度1.454±0.06 g/cm3(Predicted)
儲存條件Refrigerator
溶解度Aqueous Acid (Slightly), DMSO (Sparingly)
酸度系數(shù)(pKa)2.13±0.23(Predicted)
形態(tài)Solid
顏色Pale Yellow to Yellow
應(yīng)用領(lǐng)域
用途1
7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readil y enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.