76956-02-0
76956-02-0 結(jié)構(gòu)式
基本信息
中文別名
拉伏替丁 英文別名
Loxtidinaloxtidine
AH-234844
Lavoltidine
Lavoltidina
Lavoltidinum
Lavoltidine [inn:ban]
Lavoltidinum [inn-latin]
Lavoltidina [inn-spanish]
86160-82-9 (Hemisuccinate[1:1])
常見問題列表
生物活性
Lavoltidine (Loxtidine) 是一種具有口服活性的，不可逆且高效的組胺 H2 受體拮抗劑。Lavoltidine 強(qiáng)烈抑制胃酸分泌，并誘發(fā)高胃泌素血癥。靶點(diǎn)
|
H 2 Receptor
|
體內(nèi)研究
Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in
H felis
-infected INS-GAS mice.
Lavoltidine treatment for 6 months inhibits gastric tumors in
H felis
-infected INS-GAS mice.
| Animal Model: | Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis |
| Dosage: | 0.5 g/L |
| Administration: | Orally (drinking water); changed weekly; for 3 months |
| Result: | Showed partial suppression of both gastric acid secretion and progression to neoplasia. |