78331-26-7
中文名稱
DerMorphin Trifluoroacetate
英文名稱
DerMorphin Trifluoroacetate
CAS
78331-26-7
分子式
C42H51F3N8O12
分子量
916.91
MOL 文件
78331-26-7.mol
78331-26-7 結(jié)構(gòu)式
常見問題列表
生物活性
Dermorphin TFA 是在兩棲類皮膚中發(fā)現(xiàn)的一種天然七肽 μ-阿片受體 (MOR) 激動劑。Dermorphin 可用于抑制神經(jīng)痛。靶點
μ-opioid receptor (MOR)
體外研究
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO hMu , Dermorphin and DeNo displac the binding of [ 3 H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ 3 H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ 35 S] in a concentration dependent and saturable manner at the Mu receptor.