78441-82-4
中文名稱
BMY-25271
英文名稱
N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
CAS
78441-82-4
分子式
C12H19N5O2S2
分子量
329.44
MOL 文件
78441-82-4.mol
78441-82-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10575 英文別名
BMY-25271N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
1,2,5-Thiadiazole-3,4-diamine, N3-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-, 1-oxide
常見問(wèn)題列表
生物活性
BMY-25271 是一個(gè)組胺 H2 受體 (histamine H2 receptor) 拮抗劑。靶點(diǎn)
Histamine H2 receptor
體內(nèi)研究
BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED 50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid.