785835-79-2
中文名稱
(3R)-1,2,3,4-四氫-7-羥基-N-[(1S)-1-[[(3R,4R)-4-(3-羥基苯基)-3,4-二甲基-1-哌啶基]甲基]-2-甲基丙基]-3-異喹啉甲酰胺鹽酸鹽
英文名稱
JDTic (2HCl)
CAS
785835-79-2
分子式
C28H40ClN3O3
分子量
502.1
MOL 文件
785835-79-2.mol
更新日期
2024/11/15 18:20:27
785835-79-2 結(jié)構(gòu)式
基本信息
中文別名
(3R)-1,2,3,4-四氫-7-羥基-N-[(1S)-1-[[(3R,4R)-4-(3-羥基苯基)-3,4-二甲基-1-哌啶基]甲基]-2-甲基丙基]-3-異喹啉甲酰胺鹽酸鹽 英文別名
CS-648JDTic (2HCl)
JDTic hydrochloride
JDTic (dihydrochloride)
(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
(3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride
(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride
(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride
所屬類別
生物化工：激動(dòng)劑抑制劑常見問題列表
生物活性
JDTic dihydrochloride 是一種有效的 kappa-opioid receptors (KOR) 的拮抗劑，常用于神經(jīng)系統(tǒng)疾病的研究。體內(nèi)研究
JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats.