787623-48-7
中文名稱(chēng)
COX-2-IN-1
英文名稱(chēng)
1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline
CAS
787623-48-7
分子式
C18H14ClF3N4O2S
分子量
442.843
MOL 文件
787623-48-7.mol
更新日期
2023/03/17 20:03:06
787623-48-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10033化合物COX-2-IN-1
英文別名
COX-2-IN-11-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline
4-(5-(7-chloro-1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
Benzenesulfonamide, 4-[5-(7-chloro-1H-indol-3-yl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
常見(jiàn)問(wèn)題列表
生物活性
COX-2-IN-1 是 一個(gè)強(qiáng)效的 COX-2 抑制劑，其 IC50 值為 3.9 μM。靶點(diǎn)
|
COX-2 3.9 μM (IC 50 ) |
體外研究
COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC 50 s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.