79640-70-3
中文名稱
Methotrexate α-tert-Butyl Ester
英文名稱
Methotrexate α-tert-Butyl Ester
CAS
79640-70-3
分子式
C24H30N8O5
更新日期
2026/05/27 08:48:22
分子量
510.55
MOL 文件
79640-70-3.mol
79640-70-3 結(jié)構(gòu)式
基本信息
中文別名
187819 英文別名
Methotrexate α-tert-Butyl Ester(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
熔點(diǎn)>211°C (dec.)
密度1.377±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C Freezer
溶解度Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
酸度系數(shù)(pKa)4.43±0.10(Predicted)
形態(tài)Solid
顏色Pale Yellow to Orange
InChIKeyHTMMDBDGHQUHPW-INIZCTEOSA-N
SMILESNC1=NC(=NC2N=CC(=NC=21)CN(C1C=CC(=CC=1)C(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C)C)N
Methotrexate α-tert-Butyl Ester價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-133887 | Methotrexate α-tert-butyl ester | 79640-70-3 | 5 mg | 2800元 |
| 2025/12/22 | HY-133887 | Methotrexate α-tert-butyl ester | 79640-70-3 | 10 mg | 4500元 |
常見(jiàn)問(wèn)題列表
生物活性
Methotrexate α-tert-butyl ester，經(jīng) OtBu 修飾，顯著降低 HT1080 荷瘤小鼠的腫瘤生長(zhǎng)。Methotrexate 是一種抗代謝和抗葉葉酸劑，也是一種免疫抑制劑和抗腫瘤藥物。體外研究
OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity.
體內(nèi)研究
Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice.
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo.
| Animal Model: | Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells) |
| Dosage: | 30 mg/kg |
| Administration: | Once per week for 2 weeks |
| Result: | Showed a significant (63%) reduction in tumor size on day 12. |