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79994-24-4

中文名稱 DYNORPHIN A (1-10)
英文名稱 H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
CAS 79994-24-4
分子式 C57H91N19O12
分子量 1234.45
MOL 文件 79994-24-4.mol
更新日期 2026/05/25 17:19:46
79994-24-4 結(jié)構(gòu)式 79994-24-4 結(jié)構(gòu)式

基本信息

中文別名
DYNORPHIN A (1-10), PORCINE,YGGFLRRIRP
英文別名
YGGFLRRIRP
DYNORPHIN A (1-10)
Porcine dynorphin A(1-10)
DYNORPHIN A (1-10), PORCINE
dynorphin A, porcine, fragment 1-10
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO
dynorphin A fragment 1-10 porcine*sequence
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST

物理化學(xué)性質(zhì)

儲(chǔ)存條件-15°C
溶解度Soluble in DMSO
序列Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

常見問題列表

生物活性
Dynorphin A (1-10) 是一種內(nèi)源性的阿片樣神經(jīng)肽,與 κ 阿片受體 (κ-opioid receptor) 結(jié)合。Dynorphin A (1-10) 也阻斷 NMDA 激活的電流,IC50 為 42.0 μM。
靶點(diǎn)

κ-opioid receptor
NMDA receptor

體外研究

Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC 50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors.

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