79994-24-4
79994-24-4 結構式
基本信息
DYNORPHIN A (1-10)
Porcine dynorphin A(1-10)
DYNORPHIN A (1-10), PORCINE
dynorphin A, porcine, fragment 1-10
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO
dynorphin A fragment 1-10 porcine*sequence
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST
常見問題列表
κ-opioid receptor
NMDA receptor
Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC 50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors.