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82-08-6

中文名稱 粗糠柴苦素
英文名稱 ROTTLERIN
CAS 82-08-6
EINECS 編號 201-395-4
分子式 C30H28O8
MDL 編號 MFCD00017361
分子量 516.54
MOL 文件 82-08-6.mol
更新日期 2026/02/25 13:56:15
82-08-6 結構式 82-08-6 結構式

基本信息

中文別名
粗糠柴苦素
咖馬林/粗糠柴苦素
咖馬林
英文別名
3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE
MALLOTOXIN
ROTTLERIN
4’,6’-trihydroxy-5’-methyl-methyl)-2
acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl)
kamalin
(E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-
1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
所屬類別
生物化工:提取物

物理化學性質(zhì)

熔點200 °C
熔點200 °C
沸點521.39°C (rough estimate)
密度1.2051 (rough estimate)
折射率1.4900 (estimate)
儲存條件2-8°C
儲存條件2-8°C
溶解度溶于DMSO(高達50mg/ml)。
酸度系數(shù)(pKa)6.92±0.40(Predicted)
形態(tài)粉末
顏色橙色到棕色
生物來源plant (Mallotus philippinensis)
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲存1個月。
InChIKeyDEZFNHCVIZBHBI-ZHACJKMWSA-N
SMILESO1C(C=Cc2c1c(c(c(c2O)Cc4c(c(c(c(c4O)C(=O)C)O)C)O)O)C(=O)\C=C\c3ccccc3)(C)C
LogP8.660 (est)
CAS 數(shù)據(jù)庫82-08-6(CAS DataBase Reference)

安全數(shù)據(jù)

危險品標志Xn
危險類別碼20/21/22-22
危險類別碼R20/21/22
安全說明36/37-24/25
安全說明S36/37
WGK Germany3
WGK Germany3
RTECS號AM6913800
海關編碼29329990
存儲類別11 - Combustible Solids

知名試劑公司產(chǎn)品信息

粗糠柴苦素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/03/0332849粗糠柴毒素
Rottlerin, 95+%, Thermo Scientific Chemicals
82-08-610mg1309元
2026/03/03S7862粗糠柴苦素
Rottlerin
82-08-65mg970.17元
2026/03/03S7862粗糠柴苦素
Rottlerin
82-08-625mg2970.13元

常見問題列表

生物活性
Rottlerin (Mallotoxin, NSC 56346, NSC 94525)是一種從 Mallotus Philippinensis 純化出來的天然化合物,一種特效的 Protein kinase 的抑制劑,對PKCδ(來自桿狀病毒感染的Sf9昆蟲細胞)、PKCδ(來自豬脾)和CaM kinase III的IC50值分別為3 μM、6 μM和5.3 μM。Rottlerin 還可以抑制PKCα、PKCγ、PKCβ、PKCη、CKII和PKA,其IC50值分別為30 μM、40 μM、42 μM、82 μM、30 μM和78 μM。
靶點
TargetValue
PKCδ
(Cell-free assay)
3 μM
CKIII
(Cell-free assay)
5.3 μM
PKCα
(Cell-free assay)
30 μM
CKII
(Cell-free assay)
30 μM
PKCγ
(Cell-free assay)
40 μM
體外研究

Rottlerin (20 μM, 2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC.
Rottlerin (20 μM) exhibits cell proliferation in HMVEC.

Western Blot Analysis

Cell Line: Primary HMVEC (Human Microvascular Endothelial Cell).
Concentration: 20 μM.
Incubation Time: 2, 6, 24 hours.
Result: Dramatically decreased the cyclin D-1 mRNA levels in a time-dependent manner. After 2 h of treatment, the mRNA level was reduced to 50% of the control, to circa 40% after 6 h, and to 20% after 24 h. Consistently, a similar trend was observed in the protein levels, where the decrease was circa 50% after 2 h, 80% after 6 h, and to almost undetectable levels after 24 h.

Cell Proliferation Assay

Cell Line: Primary HMVEC (Human Microvascular Endothelial Cell).
Concentration: 20 μM.
Incubation Time: 24/48 hours.
Result: Exhibited a strong growth inhibition, with a reduction in thymidine incorporation respect to the control cells (DMSO 0.1%) of circa 75% and 80%, respectively.
體內(nèi)研究

Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity.
Rottlerin inhibits tumor cell proliferation, and induces apoptosis through activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP).

Animal Model: Balb C nude mice (4-6 weeks old) with AsPC-1 cells (2×10 6 cells mixed with Matrigel, 50:50 ratio) injection.
Dosage: 0 or 20 mg/kg.
Administration: Gavage 5 days per week, once daily, for 6 weeks.
Result: Inhibited AsPC-1 pancreatic tumor growth in Balb C nude mice and had no effect on the body weight of AsPC-1 tumor-bearing mice.
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