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83474-08-2

中文名稱(chēng) FENMETOZOLE TOSYLATE
英文名稱(chēng) Fenmetozole (Tosylate)
CAS 83474-08-2
分子式 C17H18Cl2N2O4S
分子量 417.307
MOL 文件 83474-08-2.mol
83474-08-2 結(jié)構(gòu)式 83474-08-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T11272
英文別名
Fenmetozole (Tosylate)

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

常見(jiàn)問(wèn)題列表

生物活性
Fenmetozole Tosylate 是乙醇的拮抗劑,同時(shí)對(duì) α2-adrenergic receptor 起拮抗作用,具有抗抑郁的功效。
體外研究

Fenmetozole acts as an antagonist of α2-adrenergic receptor.

體內(nèi)研究

In mice, fenmetozole antagonizes both the ethanol induced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg. Moreover, fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue. Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding. Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats. Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content. Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats.

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