83688-84-0
中文名稱
TERTATOLOL
英文名稱
1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol
CAS
83688-84-0
分子式
C16H25NO2S
分子量
295.44
MOL 文件
83688-84-0.mol
83688-84-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T17041 英文別名
rac TertatololEinecs 280-519-9
Racemic teraterol
RaceMic Tertatolol
Tertatolol [ban:inn]
83688-85-1 (Hydrochloride)
1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol
2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-
1-[[(3,4-Dihydro-2H-1-benzothiopyran)-8-yl]oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol
物理化學(xué)性質(zhì)
熔點(diǎn)70-72 °C
沸點(diǎn)465.0±45.0 °C(Predicted)
密度1.112±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.84±0.20(Predicted)
常見問題列表
生物活性
Tertatolol 是一種有效的 beta-adrenoceptor 和 5-HT receptor 拮抗劑，具有舒張血管的作用。體外研究
In serum-free media, tertatolol does not significantly alter the incorporation of 3 H-thymidine after 28 h of incubation in human mesangial cell (HMC). In the presence of 1% serum, tertatolol significantly reduces 3 H-thymidine incorporation. Tertatolol also inhibits 3 H incorporation when PDGF and thrombin are used as the stimulus. Tertatolol inhibits the reduction in planar surface area of HMC induced by angiotensin II. The inhibitory effect of tertatolol on HMC proliferation is also potentiated by ritanserin and MDL 72222, 5HT2 and 5HT3 antagonists, respectively.