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84746-43-0

中文名稱 MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
英文名稱 SCPB
CAS 84746-43-0
分子式 C52H80N14O11S2
分子量 1141.41
MOL 文件 84746-43-0.mol
84746-43-0 結(jié)構(gòu)式 84746-43-0 結(jié)構(gòu)式

基本信息

中文別名
小心臟活性肽B
小心臟活性肽B SCPB
英文別名
SCPB
MNYLAFPRM-NH2
SMALL CARDIOACTIVE PEPTIDE B
CARDIOACTIVE PEPTIDE B (SMALL)
Small Cardioactive Peptide B (SCPB)
SCPB Cardioactive Peptide B (sMall)
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE
H-MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
MET-ASN--LEU-ALA-PHE-PRO-ARG-MET (MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE)

物理化學性質(zhì)

密度1.41±0.1 g/cm3(Predicted)
儲存條件−20°C
酸度系數(shù)(pKa)9.82±0.15(Predicted)
形態(tài)Solid
顏色White to off-white
序列Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2

安全數(shù)據(jù)

WGK Germany3
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-P1495MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
Small Cardioactive Peptide B (SCPB)
84746-43-01mg700元
2025/12/22HY-P1495MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
Small Cardioactive Peptide B (SCPB)
84746-43-05mg1600元
2025/12/22HY-P1495MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
Small Cardioactive Peptide B (SCPB)
84746-43-010mg2300元

常見問題列表

生物活性
Small Cardioactive Peptide B (SCPB) 是一種神經(jīng)活性肽,刺激心臟和鰓組織的顆粒組分中的腺苷酸環(huán)化酶 (adenylate cyclase) 活性,EC50 分別為 0.1 和 1.0 μM。
靶點

EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)

體外研究

Small cardioactive peptide B (SCP B ) is a neurally active peptide endogenous to Aplysia . Small cardioactive peptide B (SCP B ) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP B ) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP B ) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP B ) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP B ) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC 50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP B ) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC 50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP B )is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP B ) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC 50 of 0.1 and 1.0μM, respectively.

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