847612-12-8

中文名稱化合物 T26681

英文名稱 ATL-802

CAS 847612-12-8

分子式 C24H22F3N7O3

分子量 513.47

MOL 文件 847612-12-8.mol

847612-12-8 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 應用領(lǐng)域常見問題列表

基本信息

中文別名

化合物 T26681

英文別名

ATL802
ATL-802
ATL 802

物理化學性質(zhì)

沸點738.0±70.0 °C(Predicted)

密度1.481±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)10.62±0.20(Predicted)

應用領(lǐng)域

用途一

ATL802 is an adenosine A2B Receptor antagonist. After IR, ATL802 treatment significantly improved lung function (increased pulmonary compliance and reduced airway resistance and pulmonary artery pressure) and significantly attenuated proinflammatory cytokine production, neutrophil infiltration, vascular permeability, and edema. ATL802 also significantly improved the function of DCD lungs after EVLP (increased compliance and reduced pulmonary artery pressure). After HR, A549 cells exhibited robust production of interleukin (IL)-8, a potent neutrophil chemokine, which was significantly attenuated by ATL802.

常見問題列表

概述

ATL-802 是一種強效的腺苷 A2B receptor 拮抗劑。ATL-802 有望用于糖尿病的研究。