85375-85-5
中文名稱
化合物 SKF89976A HCL
英文名稱
SK&F 89976-A
CAS
85375-85-5
分子式
C22H25NO2
分子量
335.44
MOL 文件
85375-85-5.mol
85375-85-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)531.4±50.0 °C(Predicted)
密度1.121±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)3.87±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.