85643-19-2
中文名稱
仙茅苷
英文名稱
CURCULIGOSIDE
CAS
85643-19-2
分子式
C22H26O11
分子量
466.44
MOL 文件
85643-19-2.mol
更新日期
2026/05/27 12:42:44
85643-19-2 結(jié)構(gòu)式
基本信息
中文別名
仙茅甙仙茅苷
仙茅苷(標(biāo)準(zhǔn)品)
仙茅苷(仙茅甙)
仙茅苷, 來(lái)源于仙茅
CURCULIGOSIDE 仙茅苷
英文別名
CURCULIGOSIDECurculigosideA
Curculigoside, 98%, from Curculigo orchioides Gaertn.
β-D-Glucopyranoside,2-[[(2,6-diMethoxybenzoyl)oxy]Methyl]-4-hydroxyphenyl
β-D-Glucopyranoside, 2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl
2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl beta-D-Glucopyranoside
[5-Hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl-2,6-dimethoxybenzoate
所屬類別
天然產(chǎn)物：酚類物理化學(xué)性質(zhì)
外觀性狀白色顆粒結(jié)晶，易溶于甲醇，幾乎不溶于乙醚，來(lái)源于仙茅。
熔點(diǎn)158-160 °C(Solv: methanol (67-56-1))
沸點(diǎn)734.9±60.0 °C(Predicted)
密度1.450±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度少許溶于甲醇
酸度系數(shù)(pKa)9.70±0.20(Predicted)
形態(tài)固體
顏色米白色
水溶解性sparingly soluble in water
InChIKeySJJRKHVKAXVFJQ-SPHHHMSGNA-N
SMILESC(C1C(=CC=CC=1OC)OC)(=O)OCC1C=C(O)C=CC=1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O |&1:22,23,24,26,28,r|
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P280-P305+P351+P338
安全說(shuō)明24/25
WGK GermanyWGK 3
海關(guān)編碼29389090
存儲(chǔ)類別11 - Combustible Solids
常見(jiàn)問(wèn)題列表
概述
仙茅苷有補(bǔ)腎壯陽(yáng)、益精血、強(qiáng)健筋骨、行血消腫的功效。用于腎虛不足、陽(yáng)痊遺精、虛瘦內(nèi)傷、腰脊冷痛、寒虛冷瀉、帶下、小便頻數(shù)等臨床病癥。生物活性
Curculigoside 是 C. orchioide 中的主要皂苷，具有顯著的抗氧化，抗骨質(zhì)疏松，抗抑郁和神經(jīng)保護(hù)作用。
通過(guò)調(diào)節(jié) JAK/STAT/NF-κB 信號(hào)傳導(dǎo)途徑，在體內(nèi)和體外表現(xiàn)出顯著的抗關(guān)節(jié)炎作用。靶點(diǎn)
JAK; STAT; NF-κB
體外研究
Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 μg/ml in MH7A cells. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group.
Cell Viability Assay
| Cell Line: | MH7A cells |
| Concentration: | 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml |
| Incubation Time: | 72 hours |
| Result: | Had inhibitory effect on MH7A cells. |
Western Blot Analysis
| Cell Line: | MH7A cells |
| Concentration: | 4 μg/ml; 64 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Downregulated JAK1, JAK3 and STAT3 protein expression. |