85666-17-7

中文名稱(chēng) U-63557A

英文名稱(chēng) U-63557A

CAS 85666-17-7

分子式 C15H12NNaO3

分子量 277.25

MOL 文件 85666-17-7.mol

更新日期 2026/05/28 12:24:03

85666-17-7 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 圖譜信息 U-63557A價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物 T11339
化合物FUREGRELATE SODIUM

英文別名

U-63557A
furegralate sodium
SODIUM FUREGRELATE
FUREGRELATE SODIUM
FUREGRELATE SODIUM SALT
Furegrelate Sodium (U-63557A)
Sodium 5-(3-pyridinylmethyl)-2-benzofurancarboxylate
5-(3'-Pyridinylmethyl)benzofuran-2-carboxylate sodium
sodium:5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate
5-(3-Pyridylmethyl)benzofuran-2-carboxylic acid sodium salt

物理化學(xué)性質(zhì)

儲(chǔ)存條件−20°C

溶解度DMF: >25 mg/ml; DMSO: >21 mg/ml; Ethanol: >14.5 mg/ml; PBS pH 7.2: >16.5 mg/ml

形態(tài)白色至類(lèi)白色結(jié)晶固體。

顏色White to light yellow

水溶解性Soluble in water at approximately 15mg/ml

圖譜信息

U-63557A(85666-17-7)核磁圖(¹HNMR)

U-63557A價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2025/12/22	HY-106080A	U-63557A Furegrelate sodium	85666-17-7	5mg	600元
2025/12/22	HY-106080A	U-63557A Furegrelate sodium	85666-17-7	10 mM * 1 mLin DMSO	660元
2025/12/22	HY-106080A	U-63557A Furegrelate sodium	85666-17-7	10mg	1000元

常見(jiàn)問(wèn)題列表

生物活性

Furegrelate Sodium (U-63557A) 是一種有效的、口服的、選擇性的血栓素合酶 (thromboxane synthase) 抑制劑。Furegrelate Sodium 抑制人血小板微粒體血栓素 A2 (TxA2) 合酶，其 IC50 為 15 nM。Furegrelate Sodium 正在開(kāi)發(fā)作為抗血小板藥物。

體內(nèi)研究

Furegrelate Sodium (U-63557A) (1-5 mg/kg; Oral) prevents blockage of the coronary artery.
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation.
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature.
Furegrelate also is orally available, has a long half-life of 4.2–5.8 hours in adult humans (compared to several other therapies for PAH including nitric oxide and prostacyclin analogs), and reportedly is highly specific for its target enzyme.