86484-91-5
中文名稱(chēng)
鹽酸多培沙明
英文名稱(chēng)
Dopexamine hydrochloride
CAS
86484-91-5
分子式
C22H34Cl2N2O2
分子量
429.424
MOL 文件
86484-91-5.mol
86484-91-5 結(jié)構(gòu)式
基本信息
中文別名
鹽酸多培沙明二氯化多巴檢查
鹽酸多培沙明 EP標(biāo)準(zhǔn)品
4-[2-[[6-[(2-苯乙基)氨基]己基]氨基]乙基]-1,2-苯二酚二鹽酸鹽
英文別名
Dopexamine HClDOPEXAMINE 2HCL
dopexamine hydrochloride
Dopexamine dihydrochloride CRS
4-(2-((6-(phenethylamino)hexyl)amino)ethyl)benzene-1,2-diol dihydrochloride
4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol dihydrochloride
1,2-Benzenediol, 4-(2-((6-((2-phenylethyl)amino)hexyl)amino)ethyl)-, dihydrochloride
1,2-Benzenediol,4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-, hydrochloride (1:2)
Beta Receptor,Adrenergic Receptor,Dopexamine,Inhibitor,Dopexamine hydrochloride,inhibit
所屬類(lèi)別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)213-215°C
儲(chǔ)存條件2-8°C
溶解度Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
形態(tài)Solid
顏色White to Light Grey
穩(wěn)定性Hygroscopic
主要應(yīng)用pharmaceutical (small molecule)
InChI1S/C22H32N2O2.2ClH/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19;;/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2;2*1H
InChIKeyVPDULUNRSQWWJB-UHFFFAOYSA-N
SMILES[Cl-].[Cl-].N(CCCCCCNCCc2ccccc2)CCc1cc(c(cc1)O)O.[H+].[H+]
常見(jiàn)問(wèn)題列表
生物活性
Dopexamine hydrochloride 是一種 β2 腎上腺素能受體激動(dòng)劑。靶點(diǎn)
β2 adrenergic receptor
體外研究
Dopexamine is a dopamine analogue with agonist activity at β2 and dopaminergic receptors. Dopexamine can attenuate the systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. Dopexamine is a dopamine analog that stimulates β-adrenergic and dopamine 1 and 2 receptors, conferring some vasodilatory effects. Dopexamine reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics, either blood pressure or stroke volume.