872506-67-7
中文名稱
(S)-1-((3-氯-2-甲基苯基)磺?；?-N-環(huán)己基哌啶-3-甲酰胺
英文名稱
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide
CAS
872506-67-7
分子式
C19H27ClN2O3S
分子量
398.95
MOL 文件
872506-67-7.mol
更新日期
2025/10/22 10:56:12
872506-67-7 結構式
基本信息
中文別名
11Β-HSD1抑制劑12(S)-1-((3-氯-2-甲基苯基)磺酰基)-N-環(huán)己基哌啶-3-甲酰胺
英文別名
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide物理化學性質
密度1.29±0.1 g/cm3(Predicted)
溶解度DMSO: Soluble
Methanol: Soluble
Methanol: Soluble
酸度系數(shù)(pKa)15.29±0.20(Predicted)
應用領域
用途一
INCB13739 is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) for the treatment of type 2 diabetes. INCB-13739 has high selectivity for 11beta-HSD1 over other dehydrogenases and glucocorticoid and mineralocorticoid receptors, with prolonged pharmacodynamic activity and good pharmacokinetic/pharmacodynamic properties. INCB-13739 demonstrated improved hepatic and peripheral insulin sensitivity with a satisfactory reduction in fasting plasma glucose and cholesterol