874460-46-5
中文名稱
(2R,3S)-2-[(1R)-1-[3,5-雙(三氟甲基)苯基]乙氧基]-3-(苯基)嗎啉鹽酸鹽
英文名稱
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
CAS
874460-46-5
分子式
C20H20ClF6NO2
分子量
455.83
MOL 文件
874460-46-5.mol
更新日期
2023/12/04 13:29:28
874460-46-5 結(jié)構(gòu)式
基本信息
中文別名
阿瑞匹坦雜質(zhì)7阿瑞吡坦雜質(zhì)18
阿瑞匹坦雜質(zhì)36
阿瑞匹坦雜質(zhì)SM3QF
阿瑞匹坦雜質(zhì) 3 HCL
(2R,3S)-2-[(1R)-1-[3,5-雙(三氟甲基)苯基]乙氧基]-3-(苯基)嗎啉鹽酸鹽
英文別名
Aprepitant Impurity SM3QFAprepitant Impurity 7 HCl
Aprepitant Impurity 3 HCl
Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1'S)-Aprepitant Hydrochloride
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1''S)-Aprepitant Hydrochloride is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.