87468-58-4
中文名稱
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
英文名稱
BIOTINYL-SUBSTANCE P
CAS
87468-58-4
分子式
C73H112N20O15S2
分子量
1573.93
MOL 文件
87468-58-4.mol
87468-58-4 結(jié)構(gòu)式
基本信息
中文別名
BIOTIN-SUBSTANCE P,BIOTIN-RPKPQQFFGLM-NH2 英文別名
AbaspBIOTIN-SUBSTANCE P
BIOTINYL-SUBSTANCE P
BIOTIN-RPKPQQFFGLM-NH2
alpha-Biotinyl-1-Arg-substance p
substance P, alpha-biotinyl-Arg(1) -
Substance p, alpha-biotinyl-arginine(1)-
1H-Thieno[3,4-d]imidazole,substance P deriv.
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)固體
顏色White to off-white
水溶解性Soluble in water at 2mg/ml; also soluble in acetonitrile
常見問題列表
生物活性
Biotin-Substance P (Neurokinin P) 是一種神經(jīng)肽，在中樞神經(jīng)系統(tǒng)中作為神經(jīng)遞質(zhì)和神經(jīng)調(diào)節(jié)劑。Substance P 的內(nèi)源性受體是神經(jīng)激肽1受體 (neurokinin 1 receptor，NK1R)體外研究
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.