880813-42-3

中文名稱 1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine

英文名稱 1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine

CAS 880813-42-3

分子式 C21H21N3

分子量 315.41

MOL 文件 880813-42-3.mol

更新日期 2026/07/15 17:50:52

880813-42-3 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 圖譜信息 1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine價格(試劑級) 常見問題列表

基本信息

中文別名

化合物 T10850

英文別名

CMP5,CMP 5
CMP-5 (PRMT5-IN-5)
1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine

物理化學性質(zhì)

沸點505.1±48.0 °C(Predicted)

密度1.14±0.1 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度DMSO: 125 mg/mL (396.31 mM)

酸度系數(shù)(pKa)7.28±0.20(Predicted)

形態(tài)Oil

顏色Light yellow to yellow

圖譜信息

1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine(880813-42-3)核磁圖(¹HNMR)

1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-120137	1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine CMP-5	880813-42-3	5 mg	1097元
2026/06/05	HY-120137	1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine CMP-5	880813-42-3	10 mM * 1 mL in DMSO	1206元
2026/06/05	HY-120137	1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine CMP-5	880813-42-3	10 mg	1600元

常見問題列表

生物活性

CMP-5 是一種有效的選擇性 PRMT5 抑制劑，對 PRMT1，PRMT4 和 PRMT7 酶無活性。CMP-5 在組蛋白的準備過程中，通過抑制 PRMT5 甲基轉(zhuǎn)移酶活性選擇性地阻斷 S2Me-H4R3。CMP-5 阻斷 EBV 驅(qū)動的 B 淋巴細胞轉(zhuǎn)化，但對正常 B 細胞沒有影響。

靶點

IC50: 3.7 μM (mTh1 cells), 9.2 μM (mTh2 cells)IC50: 26.9 μM (hTh1 cells), 31.6 μM (hTh2 cells)

體外研究

CMP-5 (0-100 μM; 24-72 hours) is selectively toxic to lymphoma cells, but shows a limited toxicity to normal resting B lymphocytes even after prolonged incubation.CMP-5 (40 μM; 24 hours) decreases p-BTK and pY(416)SRC expression in 60A cells when it compares to the DMSO-treated group.CMP-5 (0-40 μM; 24 hours) preferentially suppresses the proliferation of human Th1 cells over Th2 cells (43 versus 9% inhibition, respectively). The sensitivity of Th1 cells over Th2 cells to PRMT5 inhibition is different, the IC ₅₀ values are 26.9 μM and 31.6 μM in human Th1 cells and Th2 cells, respectively.CMP-5 (25 μM; 24 hours) alone inhibits mouse Th1 cell proliferation by 91%, when added different doses IL-2, IL-2 enhances proliferation and reaches a peak at 5 ng/ml.

Western Blot Analysis

Cell Line:	60A cells
Concentration:	40 μM
Incubation Time:	24 hours
Result:	Inhibited p-BTK and pY(416)SRC protein level.

Cell Viability Assay