88150-62-3
中文名稱
鄰苯二甲?；甭鹊仄?
英文名稱
Phthaloyl amlodipine
CAS
88150-62-3
EINECS 編號(hào)
413-410-3
分子式
C28H27ClN2O7
MDL 編號(hào)
MFCD07782096
分子量
538.98
MOL 文件
88150-62-3.mol
更新日期
2026/05/20 08:11:02
88150-62-3 結(jié)構(gòu)式
基本信息
中文別名
安氯地平中間體4-(2-氯苯基)-3-乙氧羰基-5-甲氧羰基-6-甲基-2-(酞酰亞氨基乙氧基)甲基-1,4-二氫吡啶
鄰苯二甲?；甭鹊仄?/span>
英文別名
3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2-PHTHALIMIDOETHOXY)METHYL-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLATEAMLODIPINE INTERMEDIATE
PHTHALOYL AMLODIPINE
3-Ethyl-5-methyl-4-(2-Chlorophenyl)-2-(2-phthalimidoethoxl)-methyl-6-methyl-1,4-dihydropyridine-3,5-Dicarboxylate
3-Ethyl-5-Methyl-4-(2-Chlorophenyl)-2-(2-Phthalimidoethoxy)Methyl-6-Methyl-1,4-Dihydro-Pyridine-3,5-Didarboxylate
3-Ethyl-5-Methyl-4-(2-Chlorophenyl)-2-(2-Phthalimidoethoxy)Methyl-6-Methyl-1,4-Dihydro-Pyridine-3,5-Dicarboxylate
3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxyl)methyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine
Phthalimidoamlodipine
3-ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-[2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymethyl]-6-methyl-3,5-pyridinedicarboxylate
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)140-145°C
沸點(diǎn)654.1±55.0 °C(Predicted)
密度1.321±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度可溶于DMSO（輕微）、甲醇（輕微、加熱和超聲處理）
酸度系數(shù)(pKa)2.06±0.70(Predicted)
形態(tài)neat
顏色淡黃色至淡黃色
PH值6.78 at 20.4℃ and 10g/L
主要應(yīng)用pharmaceutical (small molecule)
InChIKeyAHHPZGUFLGCZCF-UHFFFAOYSA-N
SMILESC1(COCCN2C(=O)C3=C(C2=O)C=CC=C3)NC(C)=C(C(OC)=O)C(C2=CC=CC=C2Cl)C=1C(OCC)=O
LogP4.9 at 30℃ and pH6.79
CAS 數(shù)據(jù)庫88150-62-3(CAS DataBase Reference)
常見問題列表
概述
鄰苯二甲?；甭鹊仄阶鳛楹铣砂甭鹊仄降闹匾虚g體，對進(jìn)一步合成氨氯地平至關(guān)重要。應(yīng)用
鄰苯二甲?；甭鹊仄綖榘被惢衔?，可用作醫(yī)藥中間體。