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返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>881851-50-9

881851-50-9

中文名稱 H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
英文名稱 Larazotide
CAS 881851-50-9
分子式 C34H59N9O12
分子量 785.885
MOL 文件 881851-50-9.mol
更新日期 2026/07/22 14:16:12
881851-50-9 結(jié)構(gòu)式 881851-50-9 結(jié)構(gòu)式

基本信息

中文別名
LARAZOTIDE ACETATE (>
90%)
英文別名
Larazotide acetate
LARAZOTIDE ACETATE (> 90%)
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
所屬類別
有機原料：羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

熔點>231°C (dec.)
儲存條件Refrigerator
溶解度可微溶于水
形態(tài)固體
顏色白色
InChIKeyNYGCNONRVCGHAT-FTIBEKKFNA-N
SMILESC(O)(=O)C.C(O)(=O)CNC([C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(CNC(CN)=O)=O)C(C)C)CC(C)C)C(C)C)CCC(N)=O)=O |&1:10,17,21,25,29,r|
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-91mg480元
2026/06/05HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-95mg997元
2026/06/05HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-910mg1620元

常見問題列表

生物活性
Larazotide acetate 是一種合成肽，是一種緊密連接 (junction) 的調(diào)節(jié)劑。
靶點

Paracellular permeability

體外研究

Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.

體內(nèi)研究

When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.

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