一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>887603-94-3

887603-94-3

中文名稱 887603-94-3
英文名稱 ST101
CAS 887603-94-3
分子式 C15H12N2O
分子量 236.27
MOL 文件 887603-94-3.mol
更新日期 2024/11/15 18:20:28
887603-94-3 結(jié)構(gòu)式 887603-94-3 結(jié)構(gòu)式

基本信息

中文別名
1',3'-二氫-2H-螺[咪唑并[1,2-A]吡啶-3,2'-茚]-2-酮
英文別名
ST101
ZSET 1446
ST 101(ZSET1446)
ST101
ZSET-1446
ZSET 1446
ST-101
ST 101
1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE
Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-
所屬類別
生物化工:激動劑抑制劑

物理化學性質(zhì)

沸點403.4±55.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 34 mg/mL (143.90 mM)
酸度系數(shù)(pKa)3.13±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to khaki
887603-94-3價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-11013887603-94-3
ZSET1446
887603-94-35mg1185元
2026/06/05HY-11013887603-94-3
ZSET1446
887603-94-310mM * 1mLin DMSO1303元
2026/06/05HY-11013887603-94-3
ZSET1446
887603-94-310mg1860元

常見問題列表

生物活性
ZSET1446 是一種新穎的促進認知藥,在不同的阿爾茨海默病模型中,能夠改善學習功能障礙。
體外研究

ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 μM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM.

體內(nèi)研究

ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus.

"887603-94-3" 相關產(chǎn)品信息
324077-62-5 887603-94-3
合作市| 甘德县| 柳江县| 双流县| 区。| 北碚区| 霍州市| 恩施市| 桐梓县| 三亚市| 大庆市| 三原县| 招远市| 道孚县| 武义县| 微博| 禄丰县| 凤冈县| 宜城市| 丹阳市| 安庆市| 金沙县| 涟水县| 灌南县| 洱源县| 抚州市| 论坛| 湘潭县| 吉木萨尔县| 任丘市| 兴宁市| 扎兰屯市| 和顺县| 镇远县| 文水县| 固始县| 西乡县| 怀仁县| 吉安市| 开远市| 长白|