89750-14-1
中文名稱
glucagon-like peptide 1
英文名稱
glucagon-like peptide 1
CAS
89750-14-1
分子式
C149H226N40O45
分子量
3297.63
MOL 文件
89750-14-1.mol
更新日期
2026/05/29 13:09:21
89750-14-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
序列H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
應(yīng)用領(lǐng)域
多肽
胰高血糖素樣肽是人體分泌的一種腸道激素，由胰高血糖素原(Proglucagon)分子經(jīng)腸道蛋白水解酶作用而產(chǎn)生，因而稱為胰高血糖素類多肽。胰高血糖素樣肽-1是由30個(gè)氨基酸殘基組成的多肽，肽鏈C端乙?；?；另一種為GLP-1(7-37)，是由31個(gè)氨基酸殘基組成的多肽。GLP-1(7-36)和GLP-1(7-37)有相同的促胰島素分泌作用。研究表明當(dāng)血糖濃度高于6mmol/L時(shí)，GLP-1能顯著促進(jìn)胰島素分泌；而一旦血糖濃度恢復(fù)至正常值則不再繼續(xù)作用，在臨床上這一點(diǎn)對(duì)II型糖尿病的治療十分有用。用途一
GLP-1 stimulates pancreatic β cells to secrete insulin as
an incretin hormone. GLP-1 also has additional actions,
including suppression of glucagon secretion, inhibition of
gastric motility, and promotion of satiety. GLP-1 was first identified in the early 1980s, following
the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the
N-terminal extended forms of GLP-1(1–37 and 1–36
amide). However, these forms were devoid of biological
activity. In the late 1980s, bioactive GLP-1 peptides were
purified from gut extracts and were identified to be GLP-1(7–37) and GLP-1(7–36)-amide. In the current literature,
the unqualified designation of GLP-1 corresponds to the
truncated peptides.參考質(zhì)量標(biāo)準(zhǔn)
外觀:白色粉末純度(HPLC) ≥95.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%