89947-79-5
中文名稱
1-PALMITOYL-2-GLUTARYL-SN-GLYCERO-3-PHOSPHOCHOLINE;PGPC
英文名稱
1-PALMITOYL-2-(4-CARBOXYBUTANOYL)-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
CAS
89947-79-5
分子式
C29H56NO10P
分子量
609.74
MOL 文件
89947-79-5.mol
更新日期
2026/04/03 08:24:02
89947-79-5 結(jié)構(gòu)式
基本信息
中文別名
(2S,5S)-5-氨基-7-羧基-1-羥基-4-氧代-3-(棕櫚酰氧基)庚烷-2-基-(2-(三甲基氨)乙基) 磷酸鹽 英文別名
PGPC1-palMitoyl-2-glutaryl-sn-glycero-3-phosphocholine
1-PALMITOYL-2-GLUTARYL-SN-GLYCERO-3-PHOSPHOCHOLINE
PGPC
1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine, powder
1-PALMITOYL-2-(4-CARBOXYBUTANOYL)-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
(2S,5S)-5-Amino-7-carboxy-1-hydroxy-4-oxo-3-(palmitoyloxy)heptan-2-yl (2-(trimethylammonio)ethyl) phosphate
應(yīng)用領(lǐng)域
用途一
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate polymorphonuclear leukocytes. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. One of these substances isolated from oxLDL and identified as azelaoyl PAF is a potent PPARγ agonist. 1-Palmitoyl-2-glutaryl phosphatidylcholine (PGPC) and 1-(palmitoyl)-2-(5-oxovaleroyl) phosphatidylcholine (POV-PC) are closely related compounds with strikingly different activity. PGPC treatment of vascular endothelial cells induces the expression of both E-selectin and VCAM-1, and increases endothelial cell binding by both neutrophils and monocytes. This contrasts with POV-PC treatment, which stimulates only monocyte binding, and strongly inhibits the LPS-induced binding of neutrophils.[Cayman Chemical]