9072-41-7
中文名稱(chēng)
MOTILIN (HUMAN, PORCINE)
英文名稱(chēng)
MOTILIN (HUMAN, PORCINE)
CAS
9072-41-7
分子式
C120H188N34O35S
分子量
2699.05
MOL 文件
9072-41-7.mol
9072-41-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.48±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly; PBS (pH 7.2): 5 mg/ml
形態(tài)結(jié)晶固體
序列Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln
應(yīng)用領(lǐng)域
用途一
Motilin is a polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting. In isolated rabbit duodenal segments, porcine motilin (10 nM-1 μM) induced phasic contractions and acetylcholine release from enteric neurons (EC50 = 2.5 nM). Formulations containing motilin are used to increase gastrointestinal motility in patients with diabetic gastroparesis, often in combination with erythromycin , an antibiotic and agonist at the motilin receptor.