91618-36-9
91618-36-9 結(jié)構(gòu)式
基本信息
中文別名
伊巴沙星 英文別名
R835S 25930
Ibafloxacine
9-Fluoro-6,7-dihydro-5,8-dimethyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
6,7-Dihydro-9-fluoro-5,8-dimethyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5,8-dimethyl-1-oxo-
物理化學(xué)性質(zhì)
熔點(diǎn)269-272°
沸點(diǎn)477.5±45.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.71±0.40(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Ibafloxacine (R835) 是一種專門用于獸醫(yī)用途的氟喹諾酮類抗生素。體內(nèi)研究
The pharmacokinetic behavior of Ibafloxacin is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of Ibafloxacin are determined by high-performance liquid chromatography with fluorescence detection. After IV injection Ibafloxacin shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of Ibafloxacin after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats.