91833-49-7
中文名稱
羅卡斯汀
英文名稱
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione
CAS
91833-49-7
分子式
C13H19N3OS
分子量
265.37
MOL 文件
91833-49-7.mol
91833-49-7 結構式
基本信息
中文別名
羅卡斯汀 英文別名
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f][1,4]oxazepine-5(2H)-thione
Pyrido[3,2-f]-1,4-oxazepine-5(2H)-thione, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methyl-
物理化學性質
熔點130-133 °C
沸點379.0±52.0 °C(Predicted)
密度1.20±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.18±0.28(Predicted)
常見問題列表
生物活性
Rocastine 是一種選擇性的，非鎮(zhèn)靜的 H1 拮抗劑，為抗組胺劑。體內研究
Rocastine is effective with a 15 min pretreatment time (PD 50 = 0.13 mg/kg) as it is with a 1 hr pretreatment time (PD 50 = 0.12 mg/kg). Rocastine protects guinea pigs from collapse induced by aerosolized antigen; rocastine is approximately 36x more potent than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine does not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor does it potentiate yohimbine toxicity in mice.