91940-87-3

中文名稱(chēng) ZATEBRADINE HCL

英文名稱(chēng) 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE

CAS 91940-87-3

分子式 C26H37ClN2O5

分子量 493.04

MOL 文件 91940-87-3.mol

更新日期 2025/10/22 10:56:12

91940-87-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 ZATEBRADINE HCL價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

鹽酸扎替雷定

英文別名

UL-FS49
ULFS 49CL
Zatebradine HCl
ZATEBRADINE HYDROCHLORIDE
Zatebradine dihydrochloride
3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
2H-3-Benzazepin-2-one, 3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
UL-FS49, 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

物理化學(xué)性質(zhì)

熔點(diǎn)188° and mp 168°

儲(chǔ)存條件2-8°C

溶解度H₂O: ~14 mg/mL

溶解度在水中的溶解度~14 mg/mL

形態(tài)solid

顏色white

水溶解性Soluble in water (100mM)

InChI1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H

InChIKeyZRNKXJHEQKMWCH-UHFFFAOYSA-N

SMILESCl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC

安全數(shù)據(jù)

安全說(shuō)明22-24/25

WGK Germany3

存儲(chǔ)類(lèi)別11 - Combustible Solids

圖譜信息

ZATEBRADINE HCL(91940-87-3)核磁圖(¹HNMR)

ZATEBRADINE HCL價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-13422R	ZATEBRADINE HCL Zatebradine hydrochloride (Standard)	91940-87-3	5 mg	1410元
2026/06/05	HY-13422R	ZATEBRADINE HCL Zatebradine hydrochloride (Standard)	91940-87-3	10 mg	2256元
2026/06/05	HY-13422	ZATEBRADINE HCL Zatebradine hydrochloride	91940-87-3	5mg	560元

常見(jiàn)問(wèn)題列表

生物活性

Zatebradine (UL-FS-49 (free base)) 是一種高效的 HCN Channel 抑制劑，其 IC50 值為 1.96 μM。Zatebradine 會(huì)阻止通過(guò)人類(lèi) HCN1，HCN2，HCN3 和 HCN4 通道的緩慢內(nèi)向電流，其 IC50 值分別為 1.83 μM，2.21 μM，1.90 μM 和 1.88 μM。

靶點(diǎn)

IC50: 1.96 μM ( HCN channels )

體外研究

The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells has an apparent K _d of 480 nM.

體內(nèi)研究

Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED ₅₀ value of 1.8 mg/kg and induces increasing arrhythmia.

Animal Model:	Male C57/Bl6-mice
Dosage:	0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection; for 30 minutes
Result:	Observed acute blood glucose reduction, dose-dependently reduced glycated hemoglobin, significantly prevented the decrease of IRI levels at doses of 3 and 10 mg/kg, and no difference in food intake or body weight.