924377-85-5
中文名稱
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
英文名稱
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
CAS
924377-85-5
分子式
C22H25N3O2S
分子量
395.52
MOL 文件
924377-85-5.mol
924377-85-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15425 英文別名
GSK 1702934A1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
物理化學(xué)性質(zhì)
密度1.299±0.06 g/cm3(Predicted)
儲(chǔ)存條件RT
溶解度溶于DMSO（最高50mg/ml）或乙醇（加熱最高25mg/ml）
酸度系數(shù)(pKa)11.98±0.30(Predicted)
形態(tài)固體
顏色白色
穩(wěn)定性可在-20°C下的DMSO或乙醇溶液保存長(zhǎng)達(dá)2個(gè)月。
SMILESO=C1N(C2CCN(C(C3=CC(CCCCC4)=C4S3)=O)CC2)C5=CC=CC=C5N1
常見問(wèn)題列表
生物活性
GSK1702934A是一種選擇性的 TRPC3 激動(dòng)劑。GSK1702934A 通過(guò)激活 TRPC3 調(diào)節(jié)心臟收縮力和心律失常。靶點(diǎn)
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TRPC3
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體外研究
GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC
50
of 0.08 mM and 0.44 mM, respectively.
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes.
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes.
體內(nèi)研究
GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats.