924636-93-1
英文名稱
Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)-
CAS
924636-93-1
分子式
C22H17F3N2O
分子量
382.38
MOL 文件
924636-93-1.mol
924636-93-1 結構式
應用領域
用途一
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.