929895-45-4
中文名稱
929895-45-4
英文名稱
Phen-DC3 Trifluoromethanesulfonate
CAS
929895-45-4
分子式
C36H26F6N6O8S2
分子量
848.747
MOL 文件
929895-45-4.mol
更新日期
2024/12/03 15:40:38
929895-45-4 結(jié)構(gòu)式
基本信息
中文別名
解旋酶FANCJ和DING抑制劑 英文別名
Phen-DC3 TriflatePhen-DC3 Trifluoromethanesulfonate
所屬類別
有機(jī)原料：烴類化合物及其衍生物物理化學(xué)性質(zhì)
熔點(diǎn)>260 °C(Solv: ethyl ether (60-29-7))
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 34 mg/mL (40.06 mM)
形態(tài)Solid
顏色White to light yellow
InChIKeyPYJCATLYPXPYHF-UHFFFAOYSA-N
SMILESO=C(NC1=CC2=CC=CC=C2[N+](C)=C1)C3=CC=C4C=CC5=CC=C(N=C5C4=N3)C(NC6=CC7=CC=CC=C7[N+](C)=C6)=O.O=S([O-])(C(F)(F)F)=O.O=S([O-])(C(F)(F)F)=O
929895-45-4價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 1mg | 600元 |
| 2026/06/05 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 5mg | 1035元 |
| 2026/06/05 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 10mg | 1800元 |
常見問題列表
生物活性
Phen-DC3 Trifluoromethanesulfonate 是一個(gè) G4 特異性配體，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分別為 65±6 和 50±10 nM。靶點(diǎn)
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
體外研究
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells.