93718-83-3

中文名稱 NSC 95397

英文名稱 NSC 95397

CAS 93718-83-3

分子式 C14H14O4S2

分子量 310.39

MOL 文件 93718-83-3.mol

更新日期 2026/06/02 18:15:51

93718-83-3 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 NSC 95397價格(試劑級) 常見問題列表

基本信息

中文別名

化合物NSC 95397
2,3-雙(2-羥基乙硫基)-1,4-萘二酮

英文別名

NSC 95397
Cdc25 Inhibitor IV, NSC 95397
2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE
2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE
2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE
1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-
Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

物理化學性質(zhì)

儲存條件-20°C

溶解度DMSO: 16 mg/mL

溶解度二甲基亞砜：16 毫克/毫升

形態(tài)橙色固體

顏色orange, solid

穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或乙醇溶液可在 -20°C 下保存長達 1 個月。

InChI1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2

InChIKeyMAASHDQFQDDECQ-UHFFFAOYSA-N

SMILESOCCSC1=C(SCCO)C(=O)c2ccccc2C1=O

安全數(shù)據(jù)

危險品標志Xi

WGK Germany3

危險等級IRRITANT

存儲類別11 - Combustible Solids

圖譜信息

NSC 95397(93718-83-3)核磁圖(¹HNMR)

NSC 95397價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-108543	NSC 95397 NSC 95397	93718-83-3	1 mg	516元
2026/06/05	HY-108543	NSC 95397 NSC 95397	93718-83-3	5mg	1200元
2026/06/05	HY-108543	NSC 95397 NSC 95397	93718-83-3	10mM * 1mLin DMSO	1320元

常見問題列表

生物活性

NSC 95397 是一種有效的、選擇性 Cdc25 雙特異性磷酸酶抑制劑，對于 Cdc25A、Cdc25B 和 Cdc25C 的Ki值分別為32 nM、96 nM 和 40 nM。NSC 95397 對 hCdc25A、hCdc25C 和 hCdc25B 的IC50值分別為22.3 nM、56.9 nM和125 nM。NSC 95397 抑制 mitogen-activated protein kinase phosphatase-1 (MKP-1) 和增殖，并通過 MKP-1 和 ERK1/2 途徑誘導結(jié)腸癌細胞凋亡。

靶點

Target	Value
MKP-1 ()
Cdc25A (Cell-free assay)	22.3 nM
Cdc25A (Cell-free assay)	32 nM(Ki)
Cdc25C (Cell-free assay)	40 nM(Ki)
Cdc25B (Cell-free assay)	56.9 nM

體外研究

NSC 95397 (0, 10, and 20 μM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner.
NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells.
NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811.
NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels.
NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204.

Cell Viability Assay

Cell Line:	Human colon cancer cell lines, SW480, SW620, and DLD-1
Concentration:	0, 10, and 20 μM
Incubation Time:	24 hours
Result:	The IC ₅₀ values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively.

Western Blot Analysis

Cell Line:	SW480, SW620, and DLD-1 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811