93908-02-2
93908-02-2 結(jié)構(gòu)式
基本信息
中文別名
蝴蝶霉素瑞貝卡霉素
瑞貝卡霉素雜質(zhì)
英文別名
NSC 359079REBECCAMYCIN
dro-12-(4-o-methyl-beta-d-glucopyranosyl)-
REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES
5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy
1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-
7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
常見問題列表
生物活性
Rebeccamycin，一種抗腫瘤抗生素，抑制 DNA 拓?fù)洚悩?gòu)酶 I (DNA topoisomerase I)。Rebeccamycin 通過毒害拓?fù)洚悩?gòu)酶 I 發(fā)揮其主要的抗腫瘤作用，對蛋白激酶 C 和拓?fù)洚悩?gòu)酶 Ⅱ 的作用較小。靶點
|
Topoisomerase I
|
Traditional Cytotoxic Agents
|
體外研究
Rebeccamycin is an antitumor antibiotic produced by the actinomycete
Saccharotrix aerocolonigenes
with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including
Staphylococcus aureus
and
Streptococcus faecalis
.
體內(nèi)研究
Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.
| Animal Model: | CDF1 mice (B16 melanoma, L1210 leukemia) |
| Dosage: | 2, 4, 8, 16, 32, 64, 128, 256 mg/kg |
| Administration: | I.p.; daily for 9 days |
| Result: | Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg. |