947669-86-5

中文名稱 WWL113

英文名稱 WWL113

CAS 947669-86-5

分子式 C29H26N2O4

分子量 466.528

MOL 文件 947669-86-5.mol

947669-86-5 結構式

基本信息物理化學性質安全數(shù)據(jù) WWL113價格(試劑級) 常見問題列表

基本信息

中文別名

化合物 T17259

英文別名

WWL113
AKIIPHDGVCFVCC-UHFFFAOYSA-N
ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate
4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester

物理化學性質

沸點630.9±55.0 °C(Predicted)

密度1?+-.0.06 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.1 mg/ml

酸度系數(shù)(pKa)5.18±0.26(Predicted)

形態(tài)結晶固體

顏色White to off-white

InChI1S/C29H26N2O4/c1-3-34-28(32)25-9-7-22(8-10-25)23-11-13-27(14-12-23)35-29(33)31(2)20-21-5-4-6-26(19-21)24-15-17-30-18-16-24/h4-19H,3,20H2,1-2H3

InChIKeyAKIIPHDGVCFVCC-UHFFFAOYSA-N

SMILESCCOC(C(C=C1)=CC=C1C(C=C2)=CC=C2OC(N(C)CC3=CC(C4=CC=NC=C4)=CC=C3)=O)=O

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

WWL113價格(試劑級)

報價日期	產品編號	產品名稱	CAS號	包裝	價格
2025/12/22	HY-110148	WWL113 WWL113	947669-86-5	5 mg	800元
2025/12/22	HY-110148	WWL113	947669-86-5	10 mM * 1 mLin DMSO	820元
2025/12/22	HY-110148	WWL113 WWL113	947669-86-5	10 mg	1400元

常見問題列表

生物活性

WWL113 是具有口服活性的、選擇性的 Ces3 和 Ces1f 的抑制劑，其對 Ces3 和 Ces1f 的 IC50 值分別為 120 nM 和 100 nM。WWL113 對 60-kDa絲氨酸水解酶(或水解酶)有極好的選擇性。

靶點

IC50: 120 nM (Ces3), 100 nM (Ces1f).

體外研究

Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes.
WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.

體內研究

WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance.
WWL113 ameliorates obesity-diabetes in mice.