955121-65-0
英文名稱
Pyrimido[2,1-f]purine-2,4(1H,3H)-dione, 6,7,8,9-tetrahydro-9-[2-(1H-indol-3-yl)ethyl]-1,3-dimethyl-
CAS
955121-65-0
分子式
C20H22N6O2
分子量
378.43
MOL 文件
955121-65-0.mol
955121-65-0 結(jié)構(gòu)式
基本信息
英文別名
PSB-KD107Pyrimido[2,1-f]purine-2,4(1H,3H)-dione, 6,7,8,9-tetrahydro-9-[2-(1H-indol-3-yl)ethyl]-1,3-dimethyl-
物理化學(xué)性質(zhì)
熔點(diǎn)230-232 °C(Solv: 1-propanol (71-23-8))
沸點(diǎn)661.5±65.0 °C(Predicted)
密度1.47±0.1 g/cm3(Predicted)
溶解度DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
酸度系數(shù)(pKa)17.31±0.30(Predicted)
形態(tài)A crystalline solid
應(yīng)用領(lǐng)域
用途一
PSB-KD107 is an agonist of the Cannabinoid-Activated Orphan G?Protein-Coupled Receptor GPR18. PSB-KD107 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55.