959850-74-9
中文名稱
化合物AP1189 ACETATE
英文名稱
AP1189 acetate
CAS
959850-74-9
分子式
C16H18N6O4
分子量
358.36
MOL 文件
959850-74-9.mol
更新日期
2024/07/24 18:26:20
959850-74-9 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ～3-fold.