96800-41-8
中文名稱
DUP 105
英文名稱
4-methylsulfinylphenyloxooxazolidinylmethylacetamide
CAS
96800-41-8
分子式
C13H16N2O4S
分子量
296.34
MOL 文件
96800-41-8.mol
更新日期
2023/03/17 20:03:06
96800-41-8 結(jié)構(gòu)式
基本信息
中文別名
化合物DUP 105化合物 T11123
英文別名
DuP-1054-methylsulfinylphenyloxooxazolidinylmethylacetamide
(5S)-5-Acetylaminomethyl-3-(4-methylsulfinylphenyl)oxazolidin-2-one
N-[[(5S)-3-[4-(Methylsulfinyl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide
(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide
Acetamide, N-[[(5S)-3-[4-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
常見問題列表
生物活性
DuP 105 是一種可口服的惡唑烷酮類化合物，能夠抗葛蘭素陽性菌。體外研究
DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC 90 s of 4 to 16 μg/mL and 16 μg/mL. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC 50 s) range from 4.0 to 16 μg/mL.
體內(nèi)研究
DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg.