一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>96892-57-8

96892-57-8

中文名稱 hepsulfam
英文名稱 hepsulfam
CAS 96892-57-8
分子式 C7H18N2O6S2
分子量 290.36
MOL 文件 96892-57-8.mol
96892-57-8 結(jié)構(gòu)式 96892-57-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15472
英文別名
hepsulfam
NCI 329680
NSC-329680
ZINC01574758
7-sulfamoyloxyheptyl sulfamate
Sulfamic acid, S,S'-1,7-heptanediyl ester
Bissulfamideoic acid 1,7-heptanediyl ester
Bis(amidosulfuric acid)1,7-heptanediyl ester

物理化學(xué)性質(zhì)

熔點(diǎn)94-95 °C
沸點(diǎn)478.2±55.0 °C(Predicted)
密度1.407±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.10±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
hepsulfam價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-U00095hepsulfam
Hepsulfam
96892-57-81mg400元
2026/06/05HY-U00095hepsulfam
Hepsulfam
96892-57-85mg800元
2026/06/05HY-U00095Rhepsulfam
Hepsulfam (Standard)
96892-57-81 mg2160元

常見問題列表

生物活性
Hepsulfam (NCI 329680; ZINC01574758) 是抗癌試劑,具有優(yōu)異的抗白血病活性,在不同腫瘤中的中位 IC50 值為0.91 μg/mL。
靶點(diǎn)

IC50: 0.91 μg/mL (Tumors)

體外研究

At a concentration of 1.0 μg/mL, hepsulfam is active in eight of 37 tumors (22%) in the clonogenic assay. Hepsulfam demonstrates a clear in vitro toxicity to human bone marrow cells (CFU-GM) from healthy donors. Evaluation of equitoxic concentrations in vitro reveals a higher activity of hepsulfam, especially in non-small cell lung cancer. Hepsulfam is more toxic to L1210 leukemia cells than is busulfan, its structural homologue . Consistent with the difference in toxicity, hepsulfam induces DNA interstrand cross-links in L1210 mouse leukemia cells, whereas busulfan does not. Hepsulfam is more cytotoxic to two human leukemia cell lines (111-60 and K562) and to two human colon carcinoma cell lines (BE and HT-29) than is busulfan. As in 11210 cells, hepsulfam induces a higher level of DNA interstrand cross-links than busulfan. Hepsulfam is also more cytotoxic to the human leukemia cell lines when the concentrations are reduced 10-fold and the duration of drug exposure is increased to 12 h.

體內(nèi)研究

Hepsulfam demonstrates superior in vivo activity in a large cell lung cancer xenograft and a gastric carcinoma model. The preclinical activity of hepsulfam suggests a possible role of this compound in the treatment of solid human malignancies. However, the increased bone marrow toxicity of hepsulfam as compared with busulfan might be critical for further clinical application.

"96892-57-8" 相關(guān)產(chǎn)品信息
蒲江县| 府谷县| 祁连县| 岑溪市| 开江县| 荆门市| 元朗区| 高要市| 蓝山县| 德清县| 阿合奇县| 沅陵县| 通城县| 清徐县| 仪陇县| 旌德县| 商南县| 高尔夫| 璧山县| 星子县| 江油市| 郑州市| 临澧县| 梁平县| 永泰县| 津南区| 甘孜县| 嘉黎县| 淳化县| 凤城市| 呼伦贝尔市| 策勒县| 通山县| 中卫市| 揭阳市| 林周县| 永和县| 汉阴县| 娄烦县| 连江县| 应用必备|