97559-35-8
中文名稱
ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
英文名稱
NEUROKININ A (4-10)
CAS
97559-35-8
分子式
C34H54N8O10S
分子量
766.91
MOL 文件
97559-35-8.mol
更新日期
2025/01/21 16:31:14
97559-35-8 結(jié)構(gòu)式
基本信息
中文別名
4-10-神經(jīng)激肽 A 英文別名
NKA(4-10)DSFVGLM-NH2
NEUROKININ A (4-10)
A-NEUROKININ FRAGMENT 4-10
α-neurokinin fragment 4-10
Α-NEUROKININ FRAGMENT 4-10
ALPHA-NEUROKININ FRAGMENT 4-10
Α-NEUROKININ FRAGMENT 4-10 ≥97%
ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
H-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
物理化學(xué)性質(zhì)
沸點(diǎn)1231.2±65.0 °C(Predicted)
密度1.276±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度Soluble in DMSO
酸度系數(shù)(pKa)3.69±0.10(Predicted)
形態(tài)固體
序列Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
常見(jiàn)問(wèn)題列表
生物活性
Neurokinin A (4-10) 是速激肽 NK2 受體激動(dòng)劑。靶點(diǎn)
NK 2 receptor
體外研究
Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK 2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK 2 receptor in human colon circular muscle. A high density of NK 2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding.