97938-30-2
中文名稱(chēng)
槐黃烷酮 G
英文名稱(chēng)
vexibinol
CAS
97938-30-2
分子式
C25H28O6
分子量
424.49
MOL 文件
97938-30-2.mol
更新日期
2026/06/01 16:12:52
97938-30-2 結(jié)構(gòu)式
基本信息
中文別名
苦參新醇降苦參酮
苦參總黃酮
槐黃烷酮 G
槐屬二氫黃酮G
槐黃烷酮 G、苦參新醇
英文別名
vexibinolSophoraavanone G
(S)-2,3-Dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-6-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2,4-dihydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-
所屬類(lèi)別
天然產(chǎn)物：黃酮類(lèi)化合物物理化學(xué)性質(zhì)
外觀性狀黃色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑。
熔點(diǎn)173-175℃
沸點(diǎn)659.3±55.0 °C(Predicted)
密度1.266±0.06 g/cm
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble in methanol;
酸度系數(shù)(pKa)7.66±0.40(Predicted)
形態(tài)粉末
顏色White-yellowish
水溶解性微溶于水
穩(wěn)定性感光
主要應(yīng)用food and beverages
InChIKeyXRYVAQQLDYTHCL-CMJOXMDJSA-N
SMILESO1[C@@H](CC(=O)c3c1c(c(cc3O)O)C[C@@H](CC=C(C)C)C(=C)C)c2c(cc(cc2)O)O
常見(jiàn)問(wèn)題列表
生物活性
Sophoraflavanone G (Kushenol F) 是從苦參中提取得到的，具有抗腫瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通過(guò)抑制 MAPK 相關(guān)途徑誘導(dǎo) MDA-MB-231 和 HL-60 細(xì)胞凋亡 (apoptosis)。靶點(diǎn)
IC50: 29.7 μM (MDA-MB-231 cell)
體外研究
Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC 50 value of 29.7 ± 5.2 μM<.br>