98326-32-0
98326-32-0 結(jié)構(gòu)式
基本信息
中文別名
司那佐旦 英文別名
SENAZODANUnii-427L2I2kim
6-(4-(4-Pyridinylamino)phenyl)-4,5-dihydro-3(2H)-pyridazinone
3-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydro-1H-pyridazin-6-one
3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(4-pyridinylamino)phenyl)-
常見(jiàn)問(wèn)題列表
生物活性
Senazodan 是一種 Ca2+ 感光劑，同時(shí)可抑制 PDE III 的活性。體外研究
Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhance Ca 2+ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III.