丙萘洛爾
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- CAS號(hào):
- 54-80-8
- 英文名:
- Pronetalol
- 英文別名:
- pronethalol;Inetol;Alderlin;Nethalide;Pronetalol;Pronethanol;(+/-)-Pronethalol;Naphthylisoproterenol;Pronethalol (()-Pronethalo);2-(isopropylamino)-1-(2-naphthyl)ethanol
- 中文名:
- 丙萘洛爾
- 中文別名:
- 丙萘洛爾;普羅納賽洛;丙萘洛爾(INN);(+/-)-前萘洛爾
- CBNumber:
- CB01116625
- 分子式:
- C15H19NO
- 分子量:
- 229.32
- MOL File:
- 54-80-8.mol
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丙萘洛爾化學(xué)性質(zhì)
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熔點(diǎn):
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108°
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沸點(diǎn):
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371.23°C (rough estimate)
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密度:
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1.0020 (rough estimate)
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折射率:
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1.5200 (estimate)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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13.91±0.20(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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CAS 數(shù)據(jù)庫(kù):
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54-80-8
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丙萘洛爾性質(zhì)、用途與生產(chǎn)工藝
Pronethalol ((±)-Pronethalo) 是一種非選擇性的 β-腎上腺素 (β-adrenergic) 拮抗劑。 Pronethalol 是有效的 Sox2 表達(dá)抑制劑。Pronethalol 可預(yù)防和逆轉(zhuǎn)洋地黃引起的室性心律失常，也可以限制腦動(dòng)靜脈畸形 (AVMs)。
Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment.
Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in
Mgp
–/–
mice.
丙萘洛爾
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-B1238 | 丙萘洛爾
Pronethalol | 54-80-8 | 5mg | 500元 |
| 2026/06/05 | HY-B1238 | 丙萘洛爾
Pronethalol | 54-80-8 | 10 mM * 1 mLin DMSO | 550元 |
54-80-8, 丙萘洛爾 相關(guān)搜索:
- Intermediates & Fine Chemicals
- Aromatics. Pharmaceuticals
- ALDERLIN
- 抑制劑
- 小分子抑制劑
- C15H20ClNO
- (+/-)-前萘洛爾
- 普羅納賽洛
- 丙萘洛爾(INN)
- 丙萘洛爾
- 54-80-8
- pronethalol
- Pronethalol (()-Pronethalo)
- (+/-)-Pronethalol
- 2-Naphthalenemethanol, α-[[(1-methylethyl)amino]methyl]-
- α-[[(1-Methylethyl)aMino]Methyl]-2-naphthaleneMethanol
- Nethalide
- Naphthylisoproterenol
- Inetol
- (+/-)-1-(2'-Naphthyl)-2-isopropylaMinoethanol
- 2-(isopropylamino)-1-(2-naphthyl)ethanol
- 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol
- α-[(tert-Butylamino)methyl]-2-naphthalenemethanol
- Pronethanol
- α-[[(1-Methylethyl)amino]methyl]naphthalene-2-methanol
- α-[(Isopropylamino)methyl]-2-naphthalenemethanol
- Alderlin
- Pronetalol