1-乙酰基-3-環(huán)丙基-6-氨基吲哚啉
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- CAS號(hào):
- 645419-13-2
- 英文名:
- 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone
- 英文別名:
- -yl}ethan-1-one;1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl);1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone;1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone;1-(6'-aminospiro[cyclopropane-1,3'-indoline]-1'-yl)ethanone;1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethan-1-one;Ethanone, 1-(6'-aminospiro[cyclopropane-1,3'-[3H]indol]-1'(2'H)-yl)-;1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone - [A14989];1-{6'-amino-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-1'-yl}ethan-1-one
- 中文名:
- 1-乙?；?3-環(huán)丙基-6-氨基吲哚啉
- 中文別名:
- 1-乙?；?3-環(huán)丙基-6-氨基吲哚啉;1-(6'-氨基螺[環(huán)丙烷-1,3'-吲哚啉]-1'-基)乙酮;1-{6'-氨基-1',2'-二氫螺[環(huán)丙并-1,3'-吲哚]-1'-基}乙烷-1-酮
- CBNumber:
- CB02471554
- 分子式:
- C12H14N2O
- 分子量:
- 202.25
- MOL File:
- 645419-13-2.mol
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1-乙酰基-3-環(huán)丙基-6-氨基吲哚啉化學(xué)性質(zhì)
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沸點(diǎn):
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488.1±45.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C(protect from light)
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酸度系數(shù)(pKa):
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4.06±0.20(Predicted)
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1-乙?；?3-環(huán)丙基-6-氨基吲哚啉性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
以化合物（CAS: 645419-12-1）為原料，合成1-(6'-氨基螺[環(huán)丙烷-1,3'-吲哚啉]-1'-基)乙酮的一般步驟如下：將1-乙?；?6-硝基-1,2-二氫-3-螺-1'-環(huán)丙基-1H-吲哚（383 mg，2 mmol）與Pd-C（10%，100 mg）在EtOH（50 mL）中的混合物于室溫下，在H2（1 atm）氛圍中攪拌1.5小時(shí)。反應(yīng)完成后，通過過濾移除催化劑，濾液經(jīng)減壓濃縮。所得殘余物用HCl/MeOH溶液處理，得到1-乙?；?6-氨基-1,2-二氫-3-螺-1'-環(huán)丙基-1H-吲哚（DC-2）（300 mg，收率90%）的鹽酸鹽形式。
參考文獻(xiàn)：
[1] Patent: US2011/98311, 2011, A1
[2] Patent: US2012/309758, 2012, A1
[3] Patent: WO2004/5279, 2004, A2. Location in patent: Page 170-171
1-乙?；?3-環(huán)丙基-6-氨基吲哚啉
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
1-乙?；?3-環(huán)丙基-6-氨基吲哚啉
生產(chǎn)廠家
1-乙?；?3-環(huán)丙基-6-氨基吲哚啉 圖譜信息:
645419-13-2, 1-乙?；?3-環(huán)丙基-6-氨基吲哚啉 相關(guān)搜索:
- 1-{6'-氨基-1',2'-二氫螺[環(huán)丙并-1,3'-吲哚]-1'-基}乙烷-1-酮
- 1-(6'-氨基螺[環(huán)丙烷-1,3'-吲哚啉]-1'-基)乙酮
- 1-乙?；?3-環(huán)丙基-6-氨基吲哚啉
- 645419-13-2
- 1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethan-1-one
- 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone
- 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone - [A14989]
- 1-(6'-aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone
- 1-(6'-aminospiro[cyclopropane-1,3'-indoline]-1'-yl)ethanone
- 1-{6'-amino-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-1'-yl}ethan-1-one
- Ethanone, 1-(6'-aminospiro[cyclopropane-1,3'-[3H]indol]-1'(2'H)-yl)-
- -yl}ethan-1-one
- 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)