NS-6180
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- CAS號:
- 353262-04-1
- 英文名:
- NS-6180
- 英文別名:
- NS6180;NS 6180;CS-1648;NS-6180;NS6180 >=98% (HPLC);NS6180, 10 mM in DMSO;NS6180;NS-6180;NS 6180;4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one;2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-;4-[[3-(trifluoromethyl)phenyl]methyl]-2H-1,4-benzenebenzothiazine-3(4H)-one
- 中文名:
- NS-6180
- 中文別名:
- 化合物NS6180;化合物MERICITABINE;化合物NS6180,10 MM DMSO 溶液;NS 6180,KCA3.1(IK)通道阻止器;4-[[3-(三氟甲基)苯基]甲基]-2H-1,4-苯并噻嗪-3(4H)-酮
- CBNumber:
- CB02667182
- 分子式:
- C16H12F3NOS
- 分子量:
- 323.33
- MOL File:
- 353262-04-1.mol
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NS-6180化學(xué)性質(zhì)
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沸點:
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476.9±45.0 °C(Predicted)
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密度:
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1.375±0.06 g/cm3(Predicted)
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儲存條件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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酸度系數(shù)(pKa):
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0.53±0.20(Predicted)
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形態(tài):
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powder
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顏色:
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white to beige
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InChI:
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1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
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InChIKey:
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ZUIJXKLTUFCDGO-UHFFFAOYSA-N
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SMILES:
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FC(F)(F)c1cc(ccc1)CN2c3c(cccc3)SCC2=O
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NS-6180性質(zhì)、用途與生產(chǎn)工藝
NS6180是KCa3.1離子通道高效選擇性抑制劑，IC50值9nM，阻止T細胞活化和炎癥反應(yīng)。
NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation. IC50 value: 9 nM [1] Target: KCa3.1 channel inhibitor in vitro: NS6180 inhibited cloned human KCa3.1 channels (IC50 = 9 nM) via T250 and V275, the same amino acid residues conferring sensitivity to triarylmethanes such as like TRAM-34. NS6180 inhibited endogenously expressed KCa3.1 channels in human, mouse and rat erythrocytes, with similar potencies (15–20 nM). NS6180 suppressed rat and mouse splenocyte proliferation at submicrolar concentrations and potently inhibited IL-2 and IFN-γ production, while exerting smaller effects on IL-4 and TNF-α and no effect on IL-17 production [1]. in vivo: DNBS challenged rats were treated with two doses (3 and 10 mg·kg-1 b.i.d.) of NS6180 for 7 days in direct comparison with the IBD drug sulfasalazine (300 mg·kg-1 q.d.). Both doses of NS6180 significantly improved weight gain and decreased inflammation induced swelling of the colon as determined by relative colon weight.
NS6180是KCa3.1離子通道高效選擇性抑制劑，IC50值9nM，阻止T細胞活化和炎癥反應(yīng)。
NS-6180
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-15707 | NS-6180
NS6180 | 353262-04-1 | 5mg | 585元 |
| 2026/06/05 | HY-15707 | NS-6180
NS6180 | 353262-04-1 | 10mM * 1mLin DMSO | 643元 |
353262-04-1, NS-6180 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 合成有機化合物配體
- 小分子抑制劑
- 小分子抑制劑，天然產(chǎn)物
- 化合物NS6180,10 MM DMSO 溶液
- NS 6180,KCA3.1(IK)通道阻止器
- 化合物MERICITABINE
- 化合物NS6180
- 4-[[3-(三氟甲基)苯基]甲基]-2H-1,4-苯并噻嗪-3(4H)-酮
- 353262-04-1
- 4-[[3-(trifluoromethyl)phenyl]methyl]-2H-1,4-benzenebenzothiazine-3(4H)-one
- NS6180, 10 mM in DMSO
- NS6180 >=98% (HPLC)
- 2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-
- CS-1648
- NS6180;NS-6180;NS 6180
- 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
- NS-6180
- NS6180
- NS 6180