1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
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- CAS號:
- 1610022-76-8
- 英文名:
- 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
- 英文別名:
- Nrf2 inhibitor 1;Nrf2-IN-1, 10 mM in DMSO;1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl);1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide;inhibit,Acute,leukemia,AML,myeloid,Nrf2,Inhibitor,Nrf2IN1,Keap1-Nrf2,Nrf-2-IN-1,Nrf2 IN 1;3-(4-Chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 3-(4-chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-
- 中文名:
- 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
- 中文別名:
- 化合物NRF2-IN-1;化合物NRF2-IN-1,10 MM DMSO 溶液;1-(4-(叔丁基)芐基)-3-(4-氯苯基)-N-羥基-1H-吡唑-5-甲酰胺
- CBNumber:
- CB03353619
- 分子式:
- C21H22ClN3O2
- 分子量:
- 383.87
- MOL File:
- 1610022-76-8.mol
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1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide化學(xué)性質(zhì)
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密度:
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1.23±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 260 mg/mL (677.31 mM)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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8.44±0.50(Predicted)
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顏色:
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White to off-white
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1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide性質(zhì)、用途與生產(chǎn)工藝
Nrf2-IN-1 是 Nrf2 的抑制劑，被用于急性髓性白血病 (AML) 藥物研究。
Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation.
Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell.
Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro.
Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax.
Cell Viability Assay
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Cell Line:
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THP-1 cells, HL-60 cells, U937 cells
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Concentration:
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1 μM, 5 μM, 10 μM, 20 μM
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Incubation Time:
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48 hours
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Result:
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Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours.
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Apoptosis Analysis
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Cell Line:
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THP-1 cells, HL-60 cells, U937 cells
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Concentration:
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5 μM, 10 μM
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Incubation Time:
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48 hours
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Result:
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Induced apoptosis in AML cells in vitro.
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Western Blot Analysis
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Cell Line:
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THP-1 cells, HL-60 cells, U937 cells
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Concentration:
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5 μM, 10 μM
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Incubation Time:
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48 hours
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Result:
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Triggered caspase-dependent apoptotic signaling in AML cells.
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Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs.
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-101025 | 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
Nrf2-IN-1 | 1610022-76-8 | 1 mg | 870元 |
| 2026/06/05 | HY-101025 | 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
Nrf2-IN-1 | 1610022-76-8 | 5 mg | 2100元 |
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
生產(chǎn)廠家
1610022-76-8, 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 相關(guān)搜索:
- 抑制劑
- 化合物NRF2-IN-1,10 MM DMSO 溶液
- 1-(4-(叔丁基)芐基)-3-(4-氯苯基)-N-羥基-1H-吡唑-5-甲酰胺
- 化合物NRF2-IN-1
- 1610022-76-8
- Nrf2-IN-1, 10 mM in DMSO
- inhibit,Acute,leukemia,AML,myeloid,Nrf2,Inhibitor,Nrf2IN1,Keap1-Nrf2,Nrf-2-IN-1,Nrf2 IN 1
- 1H-Pyrazole-5-carboxamide, 3-(4-chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-
- Nrf2 inhibitor 1
- 3-(4-Chlorophenyl)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-hydroxy-1H-pyrazole-5-carboxamide
- 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)
- 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide