SU 4312;NSC 86429;SU-4312;NSC-86429
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- CAS號(hào):
- 5812-07-7
- 英文名:
- SU 4312
- 英文別名:
- SU 4312;NSC 86429;SU4312(NSC86429);SU4312, 10 mM in DMSO;SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;SU4312, VEGFR and PDGFR receptor tyrosine kinase inhibitor;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro
- 中文名:
- SU 4312;NSC 86429;SU-4312;NSC-86429
- 中文別名:
- 化合物NSC 86429;3-(4-(二甲基氨基)亞芐基)吲哚啉-2-酮;化合物NSC 86429,10 MM DMSO 溶液;SU4312,VEGFR和PDGFR受體酪氨酸激酶抑制劑;3-[[4-(二甲基氨基)苯基]亞甲基]-1,3-二氫-2H-吲哚-2-酮;SU4312,VEGFR AND PDGFR RECEPTOR TYROSINE KINASE抑制劑
- CBNumber:
- CB0444460
- 分子式:
- C17H16N2O
- 分子量:
- 264.32
- MOL File:
- 5812-07-7.mol
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SU 4312;NSC 86429;SU-4312;NSC-86429化學(xué)性質(zhì)
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熔點(diǎn):
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225-232 °C
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沸點(diǎn):
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497.1±45.0 °C(Predicted)
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密度:
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1.219±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: 30 mg/mL
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形態(tài):
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Orange solid.
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酸度系數(shù)(pKa):
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12.89±0.20(Predicted)
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顏色:
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orange
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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InChI:
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1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
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InChIKey:
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UAKWLVYMKBWHMX-RVDMUPIBSA-N
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SMILES:
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CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23
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SU 4312;NSC 86429;SU-4312;NSC-86429性質(zhì)、用途與生產(chǎn)工藝
SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋體。(Z)-SU4312 抑制 PDGFR 和 FLK-1，IC50 分別為 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R，IC50 分別為 24.2，5.2，18.5，16.9 和 10.0 μM。
Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers.
SU 4312;NSC 86429;SU-4312;NSC-86429
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-100349 | SU 4312;NSC 86429;SU-4312;NSC-86429
SU4312 | 5812-07-7 | 1 mg | 400元 |
| 2026/06/05 | HY-100349 | SU 4312;NSC 86429;SU-4312;NSC-86429
SU4312 | 5812-07-7 | 5 mg | 1000元 |
SU 4312;NSC 86429;SU-4312;NSC-86429
生產(chǎn)廠家
SU 4312;NSC 86429;SU-4312;NSC-86429 圖譜信息:
5812-07-7, SU 4312;NSC 86429;SU-4312;NSC-86429 相關(guān)搜索:
3-(4-嗎啉亞芐基)吲哚啉-2-酮 su5204 SU-14813 2-[(1,2-二氫-2-氧代-3H-吲哚-3-亞基)甲基]-4-甲基-1H-吡咯-3-丙酸 格爾德霉素 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-八氫-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-3-丙酸叔丁酯 S-三苯甲基-L-半胱氨酸 替拉替尼 NULL SU4313SU-4313SU4313 N/A SU4942;SU-4942;SU4942 N-(3-氯苯基)-N-甲基-3-[[3,5-二甲基-4-[(4-甲基哌嗪-1-基)羰基-1H-吡咯-2-基]亞甲基]-2-氧代-2,3-二氫-1H-吲哚-5-磺酰胺 SU5205;SU-5205;SU5205 (E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺 AAL-993
- Angiogenesis and Metastasis
- Protein Kinase
- 小分子抑制劑
- 抑制劑
- Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR)
- Kinase/Phosphatase Biology
- Receptor Tyrosine Kinase Inhibitors
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- 5812-7-7
- 化合物NSC 86429,10 MM DMSO 溶液
- SU4312,VEGFR AND PDGFR RECEPTOR TYROSINE KINASE抑制劑
- 3-(4-(二甲基氨基)亞芐基)吲哚啉-2-酮
- SU4312,VEGFR和PDGFR受體酪氨酸激酶抑制劑
- 化合物NSC 86429
- 3-[[4-(二甲基氨基)苯基]亞甲基]-1,3-二氫-2H-吲哚-2-酮
- 5812-07-7
- 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indole-2-one
- SU4312, 10 mM in DMSO
- SU4312, VEGFR and PDGFR receptor tyrosine kinase inhibitor
- PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
- SU 4312;NSC 86429;SU-4312;NSC-86429
- SU4312(NSC86429)
- (Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE
- 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro
- SU 4312
- NSC 86429
- 3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
- 3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE
- 3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE